The Potential Application of Natural Ingredient Ivy Extract Hederagenin in Health Products

일 오후29,2025
범주:Nutraceutical Ingredients

As 한leading supplier specialising 에서high-quality plant extracts, Green Spring Technology continues to focus on natural active ingredients with marketpotenti알다.Recent scientific studies have focused on hederagenin—한natural pentacyclic triterpenoid compound 그리고its derivatives derived from plants such 로Chinese ivy—revealing its excellent health application prospects 그리고providing strong scientific support for formula innovation 에서이fields 의health supplements, functional foods, 그리고beverages.

 

Hederageninis a pentacyclic triterpenoid compound primarily derived from plants such as Chinese ivy, Cynanchum atratum, Patrinia scabiosaefolia, Paeonia lactiflora, and Acanthopanax senticosus, typically existing in the form 의saponins or saponins [1]다.Hederageninextracted from ivy exhibits various biological activities.

 

Ivy Leaves

1 Research on the relationship between Hederageninand inflammatory responses

Experimental evidence indicates that Hederagenin can effectively downregulate the expression 의multiple pro-inflammatory cytokines (such as TNF-α, IL-6, TGF-β1), which play important roles in 만성적인inflammation and the progression of various diseases.

 

Inflammation is a complex physiological response of the body to inflammatory factors, involving multiple cellular and molecular mechanisms. Zhang etal.[2] found that Hederagenin may contribute to respiratory health and is associated with the regulation of the transient 수용체potential (TRP) channel pathway.

 

Li et알다.[3] explored the potential association between Hederagenin and the NF-κB signalling pathway. Experimental data suggest that this compound may participate in 규제하는the cellular localisation of NF-κB and Smads proteins and may influence the expression levels of downstream molecules such as transforming growth factor β1 (TGF-β1). These findings provide new insights into the mechanisms underlying Hederagenin's role in inflammatory responses.

 

In the study 에 의해Ma et알다.[4], interactions between Hederagenin and the Ras protein/Jun N-terminal kinase/T-cell transcription factor 4 signalling axis were observed. Experimental data showed that the expression levels of factors such as tumour necrosis factor α, IL-6, transforming growth factor β1, and connective tissue growth factor in the serum of rats treated with this compound exhibited a downward trend, while the pathological characteristics of lung tissue also changed.

 

Wang and 자 오[5] explored the potential association between Hederagenin and the NOD-likereceptor protein 3 inflammasome and NF-κB pathway. Experimental results indicate that this compound may influence the phosphorylation process of the NF-κB pathway and is associated with the expression regulation of the NOD-like receptor protein 3 inflammasome. In a lipopolysaccharide-induced acute lung injury model, changes in the polarisation state of macrophages were observed in the compound-treated group.

 

Lee et알다.[6] found that the expression of NF-κB signalling pathway-related molecules was altered in the Hederagenin-treated group. Experimental data suggest that this compound may participate in regulating the expression of inflammatory factors such as nitric oxide synthase and cyclooxygenase-2.

 

Kim et알다.[7] investigated the role of Hederagenin in an alcoholic liver injury model, and experimental data showed changes in the expression levels of inflammatory mediators in the Hederagenin-treated group. Shen et알다.[8] observed a potential association between Hederagenin and the tyrosine kinase 2/signal transduction and transcription activator (STAT)3/MAPK signalling pathway, while also detecting changes in the expression levels of inflammatory-related cytokines.

 

Yu et 알다.[9] demonstrated that Hederagenin may participate in regulating signaling pathways such as NF-κB, MAPK, and phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt). Experimental results showed differences in the gene expression levels of apoptosis-related markers and inflammatory cytokines in the treatment group.

 

These studies suggest that Hederagenin may interact with multiple inflammation-related signalling pathways, with factors such as the IL family and tumour necrosis factor α potentially serving as regulatory targets in its action process.

 

2 Research Progress on Hederagenin Derivatives from Ivy Extracts

Due to the limitations of Hederagenin's physicochemical properties, researchers have explored its derivatives. Among these, α-Hederagenin, as a natural product molecule, has received significant attention [22].

 

Fang et al. [27] found that the expression of Sirtuin 6 protein changed in the α-Hederagenin-treated group, and simultaneously observed alterations in the expression levels of hypoxia-inducible factor 1α and c-Myc genes, which are regulators of glycolysis. Experimental data showed that the expression levels of glycolysis-related proteins also exhibited corresponding changes.

 

우et al. [28] investigated the potential association between α-Hederagenin and the glutathione synthase/glutathione/glutathione peroxidase 2 system. Experimental results indicated that this compound may influence the oxidative stress state of non-small 세포and exhibit certain interactions with cisplatin [29-30].

 

Chen et al. [31] revealed a potential link between α-Hederagenin and the Hippo signalling pathway. Data showed that the phosphorylation levels of Yes-related protein upstream kinase macrophage-stimulated 1 and L-type amino acid transporter were altered in the compound-treated group, while the cellular localisation of Yes-related protein also changed.

 

3 Broad Application Prospects

Existing research has explored Hederagenin and its derivatives from ivy extracts in multiple aspects. Hederagenin, an ivy saponin, demonstrates application potential in various health fields and may be suitable for developing functional products in the following areas:

respiratory health support, joint comfort and health, liver protection, neural health and protection, metabolic and oxidative stress regulation, etc.

 

Green Spring Technology is committed to providing customers with high-quality raw materials based on scientific research. We deeply understand the importance of plant extract raw materials in end products. Green Spring Technology has a strict quality control system to ensure the purity, active ingredient content, and batch-to-batch stability of raw materials.

 

Ivy Leaf Extract 5% Hederagenin

Our production and quality management systems strictly adhere to international standards (EP, USP, JP), ensuring that products comply with regulatory requirements in major export markets.

 

Customised solutions:We can provide Ivy Leaf Extract Powder Hederagenin-related raw materials in different specifications and with stability support to assist you in developing new product formulations based on your specific needs.

 

Please contact us at helen@greenspringbio.com.


 

참조

[1]쳉J,황T,Xue 헤데라제닌의 현재 지식과 개발 M.et al as  a  유망 한 약용 에이전트: 종합적 고찰 [J. RSC Adv, 2018, 8(43):24188-24202. DOI: 10.1039/c8ra03666g.

[2] 장 D, 태양 J, 양 B,  et  al.   치료 효과 만성 수축 손상의 만성 신경성 통증에 tetrapanax papyriferus와 hederagenin of  좌골 에 기초한 nerve rats KEGG 경로 예측 및 실험 검증 [J].  Evid 기반 Complement Alternat Med,2020,2020:2545806. DOI: 10. 1155/2020/2545806다.

[3] 리가, J 동, 샹 Y, et al.   항 염증의 heder-agenin 당뇨병 심근 증에 미치는 영향을 통해 억제 NF-κ B와 Smads 신호 통로에서 [J] type-2 당뇨 쥐 모델이다. RSC Adv, 2019, 9(45):26238-26247. DOI: 10.1039/c9ra02043h.

[4] 마 W, Huang  Q, 웅 정필 G, et  al.   이 보호 효과 heder의-agenin on 폐 섬유 증 by  regulating  Ras/JNK/NFAT4 축은 쥐 [J. Biosci Biotechnol 생화학, 2020, 84 (6):1131-1138. DOI: 10.1080/09168451다.2020년까지다.1721263다.

[5] 왕 L,  Zhao  M.   억제 of  NOD-like  receptor  단백질 3가지 염증마좀 활성화와 대식세포 M1 heder-agenin에 의한 분극화는 쥐에서 sepsis로 유발된 급성 폐 손상의 감쇠에 기여한다 [J].  생명공학, 2022년, 13 (3) :7262-7276.  DOI:  10. 1080/21655979다.2022년.2047406다.

[6]리 호소력이 공원 SM, 자오르 (Zhao R), et  al.   Hederagenin, a  의 주요 성분 (major component) clematis  mandshurica  레흐 트  루트,  흐르면서  RAW 264에서의 염증반응.7 cells  and  쥐 [J.   정수 Immunop-하마콜 (harmacol), 2015년, 29 (2):528-537.   DOI:  10.  1016/j.  intimp다. 2015년이다.10.링 해주다.

[7] 김 공전주기는, 노래 DH, 유 씨는 HS, et  al.   Hederagenin  보충제는 쥐의 알코올에 대한 pro-inflammatory와 apoptotic 반응을 완화시킨다. 영양학, 2017, 9(1):41. DOI: 10.3390/nu9010041.

[8] 센이, 텐엘 (Teng L), 쿠 Y, et  al.   Hederagenin  억제 골관절염의 진행을 개선하기 위한 염증과 연골 분해:생체 내 and  in  체외 연구 [J.   염증, 2023년, 46 (2) :  655 678 쪽. DOI: 10.1007/s10753-022-01763-5.

[9] 유 H, 노래 L, 오, X, et al.Hederagenin 흐르면서 MLK3조절에 의한 뇌허혈증/재관류 손상 신호다.  프론트 파졸 [J. 프론트 파솔, 2020, 11:1173. DOI: 10.3389/fphar.2020년까지다.01173다.

[10]린 Rm 류 L, 실바, M, et al.Hederagenin 보호 PI3K/AKT 경로의 활성화에 의해 corticosterone 유발 손상에 대한 PC12세포 [J].Front Pharmacol,2021,12:712876.DOI: 10. 3389/fphar.2021년.712876다.

[11] 리앙 BF, 후앙 F, 왕ht,et al.Involvement of norepinephrine and serotonin system in antidepressant-like. 항우울제 효과 hederagenin의 the   쥐 모델 of  예측 할 수 없는  chronic   가 벼 운  스트레스로 인한 우울증 [J. 광동 제약 Biol, 연변문학 2015년, 53 (3) :368-377 쪽.   DOI:  10. 3109/13880209다.2014년이다.922586다.

[12] 우 AG, Zeng  W, 웡 VK,  et  al.   Hederagenin  and  α-hederin 홍보 저하 단백 질의 in  신경병 성의 질병 그리고 MPTP-mice[J]의 운동결손을 개선한다.  Pharmacol Res, 2017, 115:25-44.  DOI: 10.1016/j.phrs다.2016년이다.11시 입니다.링 해주다.

[13]시 ZS, 자오 JP, Wu  LM, et  al.   헤데라게닌 (Hederagenin)은 알츠하이머병을 개선한다 을 통해  PPAR α/TFEB-mediated 오토파지 [J] .    phyto-약, 2023, 112:154711.  DOI:  10. 1016/j. phymed다. 2023년. 154711다.


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