D만 노즈 파우더 부피

D만 코파우더 대량이란?

D 망코 분말은 단당류입니다.포도당의 이성질체이며 포도당 수송 단백질을 통해 세포로 들어간다.만노스는 헥소키나아제에 의해 세포 내에서 촉매되어 만노스-6-인산염 (M6P)을 생성하며, 이는 포스포만노즈 이성질화효소 (PMI)에 의해 촉매되어 당화 경로로 진입하거나 포스포만노즈 뮤타아제 (PMM2)에 의해 당화 경로로 진입할 수 있다.

D 만노스는 특정 식물의 껍질에 자유 상태로 존재하는데, 감귤류 껍질에는 자유 상태로, 복숭아, 사과와 같은 과일에 소량의 자유 만노스가 있고, 상아야자씨, 효모, 적조류, 혈청 글로불린, 달걀 같은 뮤신, 결핵균 등에 D-mannose를 함유한 글리칸이 있다.

그린스프링 테크놀로지는 D만 코파우더를 대량 생산합니다 고순도, 낮은 내독소 함량, 낮은 콜로니 카운트, 낮은 중금속으로.ICH Q3D에 명시된 중금속 검사를 ppb (parts per billion) 이하의 농도로 실시합니다.

그린스프링은 우수한 R&D 팀, 경험이 풍부한 생산팀, 전문 영업팀을 보유하고 있습니다.당사는 체계적인 품질 관리 시스템을 갖추고 ISO, HACCP 등 품질 기준에 따라 엄격하게 생산을 조직합니다.우리는 Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO 및 기타 많은 인증을 통과했습니다.권위 있는 제3자 테스트 보고서를 제공할 수 있습니다.

규격: 

규정:

EU 규정에 부합한다.

Benefits:

Inhibiting Tumour Growth

A study reported in Nature 2018 found that D mannose powder can inhibit tumour growth by suppressing glucose metabolism by screening the effects of different hexoses on the growth of tumour cell lines. Lui Lei's team sought to explore whether various hexoses affect tumour immunity. Through screening, the researchers found that high concentrations of D-mannose were able to degrade PD-L1 protein in TNBC cells. In-depth mechanistic studies revealed that D-mannose treatment could promote the activation of AMPK, which promoted the phosphorylation of the S195 site of PD-L1 protein. The phosphorylation of this site can weaken the glycosylation of PD-L1 protein, which leads to the degradation of PD-L1 protein through proteasome.

Further studies revealed that D-mannose-mediated degradation of PD-L1 also inhibited the DNA damage repair process in tumour cells, resulting in a facilitating effect on radiotherapy for TNBC. In a mouse model of TNBC, the combination of oral D mannose and PD-1 antibody treatment significantly prolonged the survival of hormonal mice and increased CD8+ T cell infiltration and granzyme B expression in the tumour. Similarly, the combination of oral D-mannose and ionising radiation significantly inhibited tumour growth in vivo and significantly enhanced the efficacy of radiotherapy in TNBC mice.

In conclusion, this study revealed a new function of D-mannose - degradation of PD-L1 protein and reported for the first time the facilitating effect of D-mannose on immunotherapy and radiotherapy of TNBC, which provides a new strategy for the clinical treatment of TNBC.

Cell Recognition

D Mannose powder is one of the important components of cell surface glycosylation that can participate in cell recognition and interaction with the external environment.

Immunomodulation

D Mannose plays an important role in the immune system and is involved in intercellular signaling, inflammatory regulation, and activation of immune cells.

Antiviral

D mannose powder can interact with certain viral structural proteins to inhibit viral invasion and replication processes.

Applications:

For Feed Product：

Overuse of antibiotics in farming leads to the proliferation of resistant bacteria as well as pollution of the environment. Studies have demonstrated that D mannose powder can inhibit the infection of Salmonella in young chickens without side effects. Adding D mannose powder to livestock and poultry feed has the effect of inhibiting the proliferation of pathogens in the intestinal tract, protecting the health of animal intestinal tract, increasing immunity and disease resistance, and improving feed utilization.

For Health Products:

D Mannose powder has been used clinically as a glyconutrient. It can be widely distributed in body fluids and tissues, especially in the nerves, skin, testes, retina, liver, and intestine. The body can directly use mannose to synthesize glycoproteins and participate in immune regulation. In recent years, a series of surprising physiological activities of mannose, a common monosaccharide, have been revealed, including anti-inflammation, inhibition of bacterial infections, alleviation of diabetes, anti-tumor, etc. D mannose powder has been used as an additive in nutraceuticals.