에피메듐 추출 분말 Icariin

Epimedium 추출 Powder 란?

에피메디움 추출분말은 에피메디움 브레비코르눔 (brevicornum) 등의 줄기와 잎을 분말 활성 성분으로 가공한 것을 말한다.에피메듐 추출분말의 주요 활성성분은 플라보노이드이며, 이카리인, Icariin, Epimedium hypoglycoside, Epimedium macrocephaloside C, Asahioglossus glycoside A, B, C 등이 함유되어 있으며 사포닌, 쓴맛, 탄닌, 휘발성 기름, 밀랍알코올, 트리코테센, 피토스테롤, 그리고 콘드루시트르산, 올레산 등도 함유되어 있다.그들은 안드로겐과 같은 효과를 가지고, 면역력을 향상시키는 데 사용되며, 항 고혈압, 포도상 구균, 소아마비 바이러스 유도 감염은 분명한 억제 효과가 있습니다.기침 억제제, 거담제, 천식 효과도 있다.에피메듐추출분말은 주로 국제적으로 성기능을 개선하는 보건품의 원료로 사용된다.

그린 스프링 기술은 에피메듐 추출 분말 Icariin을 공급하며, 주요 활성 성분은 Icariin 이며, 함량은 5%, 10%, 20%, 60%, 98%로 다양합니다.그것은 안정적인 특성, 좋은 용해도, 낮은 수분 함량을 가지며 더 긴 기간 동안 저장 될 수 있습니다.그것의 농약 잔류, 용제 잔류 및 중금속은 유럽 약전, 일본 약전 및 미국 약전의 국제 기준에 부합한다.

그린스프링은 2000년에 설립된 중국의 대표적인 식물성 추출물 공급업체로 천연, 안전, 유기 식물성 추출물을 전문적으로 고객에게 제공하고 있다.그린스프링은 ISO, HACCP 및 기타 품질 기준에 의해 생산을 체계화합니다.당사는 제품이 국제 표준을 충족할 수 있도록 엄격한 내부 품질 관리 프로세스를 갖추고 있습니다.우리는 Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO 및 기타 많은 인증을 통과했습니다.권위 있는 타사 테스트 보고서를 사용할 수 있습니다.

규격: 

규제:

EU 규정에 부합한다.

Benefits:

Promote Reproductive System

Epimedium Extract Powder Icariin, as one of the active ingredients of Horny Goat Weed, a key medicine for tonifying the kidney and aiding the yang, can promote the function of the reproductive system. Icariin can inhibit ferrous sulfate/hydrogen peroxide-induced oxidative stress damage in human spermatozoa, activate the ERK1 /2 signaling pathway, promote the proliferation of testicular trophoblast Sertoli's, and enhance male reproductive function.

Icariin also up-regulates cytochrome P450 17 and 19 levels, promotes aromatase expression, induces proliferation of ovarian granulosa cells, and increases estrogen and progesterone production. It can also increase the weight of ovaries, uterus, and pituitary glands, promote pubertal development in female rats, and prolong the duration of estrus in pubertal rats. In addition, Icariin can reduce the levels of follicle-stimulating hormone and luteinizing hormone, increase the level of estradiol, up-regulate the expression of ovarian anti-mullerian tubular hormone, increase the Bcl-2 /Bax ratio in the ovarian tissues, improve the development of ovarian follicles in aging mice, inhibit follicular atresia, and improve their fertility.

Beneficial for Neurological Disorders

Epimedium Extract Powder Icariin have been shown to be beneficial for a variety of neurological disorders such as cerebral ischemia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and depression.

Icariin can increase the level of superoxide dismutase (SOD), reduce the expression of amyloid precursor protein and β-secretase, reduce the production and accumulation of Aβ, attenuate Aβ-mediated atrophy of axons and dendrites, and improve the spatial learning and memory ability of Alzheimer's disease model rats. Icariin can also inhibit the Aβ-induced hyperphosphorylation of serine 396, 404, and threonine 205 of tau protein, thus exerting a protective effect on nerve cells.

Icariin can inhibit NF-κB inhibitory protein α degradation and NF-κB activation, up-regulate peroxisome proliferators-activated receptors (PPARs) α and γ protein levels, and alleviate neuroinflammation. Icariin can also reduce the level of lactate dehydrogenase and malondialdehyde, weaken the activity of SOD, enhance the antioxidant ability, inhibit the increase of intracellular calcium concentration, and attenuate the neuronal damage of ischemia/reperfusion. In addition, Icariin can inhibit the activation of myelin-associated growth inhibitory factor, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein in the ischemic area, promote axon germination and regeneration, and improve nerve function.

Protecting the Skeletal System    

Epimedium Extract Powder Icariin can promote the formation and activation of osteoblasts and inhibit the formation and function of osteoclasts to alleviate osteoporosis. Icariin can activate ERα-Wnt/β-catenin and Notch signaling pathway, and up-regulate the expression of runt-related transcription factor 2, a key gene of osteoblasts, to play the role of osteogenesis. It can activate mitogen-activated protein kinase (MAPK) signaling pathway, increase the gene expression of type I collagen, osteocalcin, and osteopontin, enhance the self-renewal ability of bone mesenchymal stem cells (BMSCs) in vivo and in vitro, and induce BMSCs to develop into osteoblasts. BMSCs were induced to differentiate into osteoblasts, which in turn enhanced osteogenic differentiation. In addition, Icariin can promote the synthesis of estrogen and has an estrogen-like effect, which can activate extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), promote the proliferation of osteoblasts, activate BMP-2/Smad4, and activate BMP-2/Smad5, and activate BMP-2/Smad6, and activate BMP-2/Smad7. BMP-2/Smad4, and increased osteoblast viability.

Protection of the Cardiovascular System

Icariin can exert a protective effect on the cardiovascular system by protecting cardiomyocytes, promoting cardiomyocyte production, and improving endothelial dysfunction.

Epimedium Extract Icariin can block angiotensin II-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the activation of JNK and p38 pathways and activating ERK to scavenge reactive oxygen species and inhibit oxidative stress in cardiomyocytes. Icariin can also activate PI3K/Akt/endothelial nitric oxide synthase (eNOS) signaling pathway, reduce the level of creatine kinase, ischemia-modified albumin and lactate dehydrogenase, reduce apoptotic cells, myocardial infarction area, and improve myocardial ischemia-reperfusion injury in rats; down-regulate the activities of matrix metalloproteinases 2 and 9, and improve myocardial cell hypertrophy and apoptosis. 9 activities, improved cardiomyocyte apoptosis, and attenuated left ventricular dysfunction and cardiac remodeling.

Epimedium Extract Icariin activates the p38MAPK pathway, increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, PPARα, and nuclear respiratory factor 1, promotes the differentiation of embryonic stem cells to cardiomyocytes, and up-regulates the expression of specific myosin light chain-1v, atrial natriuretic peptide, cardiac troponin I, troponin, and sodium-calcium exchanger in differentiated cardiomyocytes, maintaining the normal functional structure of cardiomyocyte beating. In addition, Icariin can activate ERK-dependent signaling pathway and stimulate the differentiation of mouse adipose-derived stem cells into cardiomyocytes.

Regulating the Immune System

Epimedium Extract Icariin can improve the condition of autoimmune diseases such as rheumatoid arthritis, bronchial asthma, multiple sclerosis, and systemic lupus erythematosus, and is related to its regulation of lymphocyte function. Epimedium glycoside can inhibit the differentiation of helper T cells (Th) 1 and 17, and improve autoimmune encephalomyelitis in mice. Epimedium glycoside can inhibit the activation of STAT3 in T cells, downregulate the proportion of Th17 cells, inhibit the production of interleukin-17, and improve the symptoms of rheumatoid arthritis; Can regulate the proportion of Th1/Th2 cells in the lung tissue of asthmatic rats and the balance of Th17/regulatory T cells in asthmatic mice, improving asthma; It can enhance the activity of lymphokine activated killer cells and natural killer cells, and enhance the human immune system.

Applications:

For Health Products:

Icariin is the main component of epimedium extract flavonoid and also the main antioxidant active ingredient in Epimedium. Its chemical structure belongs to flavonoid compounds, which have various biological activities both in vivo and in vitro. It has a bidirectional regulatory effect on bone metabolism, including enhancing human immunity, anti-tumor and antioxidant properties, promoting tissue protein synthesis, promoting osteoblast growth, and inhibiting osteoclast activity. Epimedium extract icariin is often used as an additive in health products.

For Feed Product：

The test results showed that adding epimedium extract powder to feed promoted the development of the thymus, spleen, and bursa, improved the effect of vaccine for Newcastle disease and avian influenza, strengthened immunity, improved resistance to infectious diseases, and reduced the mortality rate as well as morbidity rate. Adding Epimedium Extract Powder Icariin to feed can prevent and control epidemic diarrhea in pigs. Rapidly regulate the intestinal physiological function of female animals and optimize the intestinal environment. Improve the reproductive ability of sows and promote the growth of animals.